UCN-02

• Description :

  UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor produced by Streptomyces strain N-12, with IC50s of 62 nM and 250 nM for PKC and protein kinase A (PKA), respectively. UCN-02 (7-epi-Hydroxystaurosporine) displays cytotoxic effect on the growth of HeLa S3 cells[1][2].

• Product Name Alternative :

  7-epi-Hydroxystaurosporine

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  PKA; PKC

• Type :

  Natural Products

• Related Pathways :

  Epigenetics; Stem Cell/Wnt; TGF-beta/Smad

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ucn-02.html

• Purity :

  98.0

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@]12N3C4=C(C5=CC=CC=C53)C([C@@H](NC6=O)O)=C6C7=C4N([C@](C[C@H]([C@H]2OC)NC)([H])O1)C8=CC=CC=C78

• Molecular Formula :

  C28H26N4O4

• Molecular Weight :

  482.53

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Takahashi I, et al. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. I. Screening, producing organism and fermentation. J Antibiot (Tokyo) . 1989 Apr;42 (4) :564-70.|[2]Takahashi I, et al. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities. J Antibiot (Tokyo) . 1989 Apr;42 (4) :571-6.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [121569-61-7]