UCN-02

CAT: 0804-HY-108262Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-108262Size:1 mg
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Description
UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor produced by Streptomyces strain N-12, with IC50s of 62 nM and 250 nM for PKC and protein kinase A (PKA), respectively. UCN-02 (7-epi-Hydroxystaurosporine) displays cytotoxic effect on the growth of HeLa S3 cells[1][2].
CAS Number
[121569-61-7]
Product Name Alternative
7-epi-Hydroxystaurosporine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PKA; PKC
Type
Natural Products
Related Pathways
Epigenetics; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ucn-02.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
C[C@]12N3C4=C(C5=CC=CC=C53)C([C@@H](NC6=O)O)=C6C7=C4N([C@](C[C@H]([C@H]2OC)NC)([H])O1)C8=CC=CC=C78
Molecular Formula
C28H26N4O4
Molecular Weight
482.53
Precautions
H302, H315, H319, H335
References & Citations
[1]Takahashi I, et al. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. I. Screening, producing organism and fermentation. J Antibiot (Tokyo) . 1989 Apr;42 (4) :564-70.|[2]Takahashi I, et al. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities. J Antibiot (Tokyo) . 1989 Apr;42 (4) :571-6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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