UCN-02

UCN-02

• CAS Number: 121569-61-7
• UNSPSC Description: UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor produced by Streptomyces strain N-12, with IC50s of 62 nM and 250 nM for PKC and protein kinase A (PKA), respectively. UCN-02 (7-epi-Hydroxystaurosporine) displays cytotoxic effect on the growth of HeLa S3 cells[1][2].
• Target Antigen: PKA; PKC
• Type: Natural Products
• Related Pathways: Epigenetics;Stem Cell/Wnt;TGF-beta/Smad
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ucn-02.html
• Purity: 98.0
• Solubility: 10 mM in DMSO
• Smiles: O=C1C2=C([C@H](O)N1)C3=C(N4C5=C3C=CC=C5)C6=C2C7=CC=CC=C7N6[C@]8([H])O[C@@]4(C)[C@H](OC)[C@H](NC)C8
• Molecular Weight: 482.53
• References & Citations: [1]Takahashi I, et al. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. I. Screening, producing organism and fermentation. J Antibiot (Tokyo). 1989 Apr;42(4):564-70.|[2]Takahashi I, et al. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities. J Antibiot (Tokyo). 1989 Apr;42(4):571-6.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported