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CLK8

CAT: 0804-HY-148765-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-148765-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CLK8 is a potent and specific CLOCK inhibitor that can disrupt the interaction between CLOCK and BMAL1 and interfere with nuclear translocation of CLOCK. CLK8 can be used for the research of disorders associated with dampened circadian rhythms[1].
CAS Number
898920-65-5
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Cryptochrome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/clk8.html
Purity
98.06
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(COC1=C(C(C2=CC=CC=C2)=CC(O3)=O)C3=C(CCC(C)(C)O4)C4=C1)NC5=C(C(N)=O)C=CC=C5
Molecular Formula
C29H26N2O6
Molecular Weight
498.53
Precautions
H315, H319, H335
References & Citations
[1]Doruk YU, et, al. A CLOCK-binding small molecule disrupts the interaction between CLOCK and BMAL1 and enhances circadian rhythm amplitude. J Biol Chem. 2020 Mar 13;295 (11) :3518-3531.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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