CLK1-IN-3
CAT:
804-HY-149262-01
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
CLK1-IN-3
- CAS Number: 2922550-28-3
- UNSPSC Description: CLK1-IN-3 (compound 10ad) is a potent and selective Clk1 inhibitor, with an IC50 of 5 nM and over 300-fold selectivity for Dyrk1A. CLK1-IN-3 also shows a relatively potent inhibition against Clk2 and Clk4, with IC50 values of 42 and 108 nM, respectively. CLK1-IN-3 potently induces autophagy in vitro. CLK1-IN-3 can be used for acute liver injury (ALI) research[1].
- Target Antigen: Autophagy; CDK; DYRK
- Type: Reference compound
- Related Pathways: Autophagy;Cell Cycle/DNA Damage;Protein Tyrosine Kinase/RTK
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/clk1-in-3.html
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: CN1CCN(CC1)C2=CC=C(C=C2)C(NC3=CN=C4NC=C(C4=C3)C5=CN=CC(F)=C5)=O
- Molecular Weight: 430.48
- References & Citations: [1]Yang T, et al. Rational design and appraisal of selective Cdc2-Like kinase 1 (Clk1) inhibitors as novel autophagy inducers for the treatment of acute liver injury (ALI). Eur J Med Chem. 2023 Mar 15;250:115168.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported