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CLK8

CAT: 0804-HY-148765-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-148765-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CLK8 is a potent and specific CLOCK inhibitor that can disrupt the interaction between CLOCK and BMAL1 and interfere with nuclear translocation of CLOCK. CLK8 can be used for the research of disorders associated with dampened circadian rhythms[1].
CAS Number
898920-65-5
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Cryptochrome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/clk8.html
Purity
98.06
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(COC1=C(C(C2=CC=CC=C2)=CC(O3)=O)C3=C(CCC(C)(C)O4)C4=C1)NC5=C(C(N)=O)C=CC=C5
Molecular Formula
C29H26N2O6
Molecular Weight
498.53
Precautions
H315, H319, H335
References & Citations
[1]Doruk YU, et, al. A CLOCK-binding small molecule disrupts the interaction between CLOCK and BMAL1 and enhances circadian rhythm amplitude. J Biol Chem. 2020 Mar 13;295 (11) :3518-3531.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

2-[[2-[(8,8-Dimethyl-2-oxo-4-phenyl-9,10-dihydropyrano[2,3-h]chromen-5-yl)oxy]acetyl]amino]benzamide
CAS Number898920-65-5
PubChem CID4869040
IUPAC Name2-[[2-[(8,8-dimethyl-2-oxo-4-phenyl-9,10-dihydropyrano[2,3-h]chromen-5-yl)oxy]acetyl]amino]benzamide
Molecular FormulaC29H26N2O6
Molecular Weight498.5
XLogP4.4
Topological Polar Surface Area117
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count37
Formal Charge0
Complexity910
SMILES
CC1(CCC2=C3C(=C(C=C2O1)OCC(=O)NC4=CC=CC=C4C(=O)N)C(=CC(=O)O3)C5=CC=CC=C5)C
InChI
InChI=1S/C29H26N2O6/c1-29(2)13-12-19-22(37-29)15-23(35-16-24(32)31-21-11-7-6-10-18(21)28(30)34)26-20(14-25(33)36-27(19)26)17-8-4-3-5-9-17/h3-11,14-15H,12-13,16H2,1-2H3,(H2,30,34)(H,31,32)
InChIKey
SVELPNHVEDZZRQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-[[2-[(8,8-Dimethyl-2-oxo-4-phenyl-9,10-dihydropyrano[2,3-h]chromen-5-yl)oxy]acetyl]amino]benzamide
CAS: 898920-65-5
CID: 4869040
Formula: C29H26N2O6
MW: 498.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight498.5
XLogP34.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass498.17908655
Monoisotopic Mass498.17908655
Topological Polar Surface Area117 Ų
Heavy Atom Count37
Formal Charge0
Complexity910
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
BA7238-25CLK8

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