CLK1/4-IN-1

CLK1/4-IN-1

• CAS Number: 3029431-90-8
• UNSPSC Description: CLK1/4-IN-1 (compound 31) is a potent and selective Clk1 and Clk4 inhibitor with an IC50 value of 9.7 nM and 6.6 nM, respectively. CLK1/4-IN-1 has growth inhibitory activities against T24 cancer cells with GI50 of 1.1 μM. CLK1/4-IN-1 can be used for researching anticancer[1].
• Target Antigen: CDK
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/clk1-4-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NC(C1=C(C=CC(Cl)=C1)OC)=O)C2=CC3=CC(OC)=CC=C3S2
• Molecular Weight: 375.83
• References & Citations: [1]El-Gamil DS, et al. Development of novel conformationally restricted selective Clk1/4 inhibitors through creating an intramolecular hydrogen bond involving an imide linker [published online ahead of print, 2022 Apr 26]. Eur J Med Chem. 2022;238:114411.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported