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CLK1/2-IN-3

CAT: 0804-HY-113831Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113831Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LK1/2-IN-3 (compound 3) is a potent and selective CLK1 and CLK2 inhibitor with IC50 values of 1.1, 2.1, 130, 260, 260 nM for CLK1, CLK2, SRPK1, SRPK2, SRPK3, respectively. CLK1/2-IN-3 shows anti-proliferative activity. CLK1/2-IN-3 reduces the levels of endogenous phosphorylated SR proteins and increases the expression of S6K mRNAs[1].
CAS Number
1005784-60-0
UNSPSC
12352005
Target
CDK; SRPK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/clk1-2-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CN2C=C(C3=CNN=C3)C=CC2=N1)C4=CC=C(C(C)(C)CO)C=C4
Molecular Formula
C21H21N5O2
Molecular Weight
375.42
References & Citations
[1]Araki S, et al. Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing. PLoS One. 2015;10 (1) :e0116929. Published 2015 Jan 12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CLK

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