Cibenzoline (succinate)

Cibenzoline (succinate)

• CAS Number: 100678-32-8
• UNSPSC Description: Cibenzoline succinate (Cifenline succinate) is the succinate form of Cibenzoline (HY-106577). Cibenzoline succinate is an inhibitor for ATP-sensitive potassium (KATP) channel by affecting the pore-forming Kir6.2 subunit with IC50 of 22.2 µM. Cibenzoline succinate affects insulin secretion and exhibits antiarrhythmic and antidiabetic activities[1].
• Target Antigen: Potassium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Field of Research: Metabolic Disease; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/cibenzoline-succinate.html
• Smiles: O=C(O)CCC(O)=O.C1(C2C(C3=CC=CC=C3)(C4=CC=CC=C4)C2)=NCCN1
• Molecular Weight: 380.44
• References & Citations: [1]Mukai E, et al., The antiarrhythmic agent cibenzoline inhibits KATP channels by binding to Kir6.2. Biochem Biophys Res Commun. 1998 Oct 20;251(2):477-81.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported