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Cibenzoline (succinate)

CAT: 0804-HY-115014Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-115014Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cibenzoline succinate (Cifenline succinate) is the succinate form of Cibenzoline. Cibenzoline succinate is an inhibitor for ATP-sensitive potassium (KATP) channel by affecting the pore-forming Kir6.2 subunit with IC50 of 22.2 µM. Cibenzoline succinate affects insulin secretion and exhibits antiarrhythmic and antidiabetic activities[1].
CAS Number
100678-32-8
Product Name Alternative
Cifenline (succinate) ; Ro 22-7796 (succinate)
UNSPSC
12352005
Hazard Statement
H302
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cibenzoline-succinate.html
Smiles
O=C(O)CCC(O)=O.C1(C2C(C3=CC=CC=C3)(C4=CC=CC=C4)C2)=NCCN1
Molecular Formula
C22H24N2O4
Molecular Weight
380.44
Precautions
P264-P270-P330-P501
References & Citations
[1]Mukai E, et al., The antiarrhythmic agent cibenzoline inhibits KATP channels by binding to Kir6.2. Biochem Biophys Res Commun. 1998 Oct 20;251 (2) :477-81.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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