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Cibenzoline (Standard)

CAT: 0804-HY-106577R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-106577R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cibenzoline (Standard) is the analytical standard of Cibenzoline. This product is intended for research and analytical applications. Cibenzoline is a class Ia antiarrhythmic active molecule with low anticholinergic activity. Cibenzoline is a KATP channel inhibitor, acting through the pore forming subunit Kir6.2, with an IC50 of 22.2 μM. Cibenzoline inhibits IKr and IKs currents with IC50 values of 8.8 μM and 12.3 μM, respectively. Cibenzoline is used in the study of cardiac diseases. In addition, Cibenzoline can induce hypoglycemia[1][2].
CAS Number
53267-01-9
Product Name Alternative
Cifenline (Standard) ; Ro 22-7796 (Standard)
UNSPSC
12352005
Target
Potassium Channel; Reference Standards
Type
Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cibenzoline-standard.html
Smiles
C1(C2CC2(C3=CC=CC=C3)C4=CC=CC=C4)=NCCN1
Molecular Formula
C18H18N2
Molecular Weight
262.35
References & Citations
[1]Mukai E, et al. The antiarrhythmic agent cibenzoline inhibits KATP channels by binding to Kir6.2. Biochem Biophys Res Commun. 1998;251 (2) :477-481.|[2]Hamada M, et al. Class Ia antiarrhythmic drug cibenzoline: a new approach to the medical treatment of hypertrophic obstructive cardiomyopathy. Circulation. 1997;96 (5) :1520-1524.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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