Cibenzoline-d4

CAT: 0804-HY-106577SSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-106577SSize:1 Each
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Description
Cibenzoline-d4 (Cifenline-d4) is deuterium labeled Cibenzoline. Cibenzoline is a class Ia antiarrhythmic active molecule with low anticholinergic activity. Cibenzoline is a KATP channel inhibitor, acting through the pore forming subunit Kir6.2, with an IC50 of 22.2 μM. Cibenzoline inhibits IKr and IKs currents with IC50 values of 8.8 μM and 12.3 μM, respectively. Cibenzoline is used in the study of cardiac diseases. In addition, Cibenzoline can induce hypoglycemia[1][2][3][4].
Product Name Alternative
Cifenline-d4; Ro 22-7796-d4
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Smiles
[2H]C1([2H])NC(C2CC2(C3=CC=CC=C3)C4=CC=CC=C4)=NC1([2H])[2H]
Molecular Formula
C18H14D4N2
Molecular Weight
266.37
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Mukai E, et al. The antiarrhythmic agent cibenzoline inhibits KATP channels by binding to Kir6.2. Biochem Biophys Res Commun. 1998;251 (2) :477-481.|[3]Hamada M, et al. Class Ia antiarrhythmic drug cibenzoline: a new approach to the medical treatment of hypertrophic obstructive cardiomyopathy. Circulation. 1997;96 (5) :1520-1524.|[4]Satoh H. Comparative actions of cibenzoline and disopyramide on I (Kr) and I (Ks) currents in rat sino-atrial nodal cells. Eur J Pharmacol. 2000 Oct 27;407 (1-2) :123-9.|[5]Takahashi Y, et al. Pharmacodynamics of cibenzoline-induced hypoglycemia in rats. Drug Metab Pharmacokinet. 2011 Jun;26 (3) :242-7.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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