Desvenlafaxine (succinate)

• UNSPSC Description:

  Desvenlafaxine succinate, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine succinate (DVS) shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter[1][2].

• Target Antigen:

  Serotonin Transporter

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/desvenlafaxine-succinate.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(O)CCC(O)=O.OC1=CC=C(C(C2(O)CCCCC2)CN(C)C)C=C1

• Molecular Weight:

  381.46

• References & Citations:

  [1]Darlene C Deecher, et al. Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor. J Pharmacol Exp Ther. 2006 Aug;318(2):657-65.|[2]Michael A Sopko Jr, et al. Desvenlafaxine: another "me too" drug? Ann Pharmacother. 2008 Oct;42(10):1439-46.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Launched

• CAS Number:

  448904-47-0