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Cibenzoline

CAT: 0804-HY-106577-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-106577-01Size:5 mg
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Description
Cibenzoline is a class Ia antiarrhythmic active molecule with low anticholinergic activity. Cibenzoline is a KATP channel inhibitor, acting through the pore forming subunit Kir6.2, with an IC50 of 22.2 μM. Cibenzoline inhibits IKr and IKs currents with IC50 values of 8.8 μM and 12.3 μM, respectively. Cibenzoline is used in the study of cardiac diseases. In addition, Cibenzoline can induce hypoglycemia[1][2][3][4].
CAS Number
[53267-01-9]
Product Name Alternative
Cifenline; Ro 22-7796
UNSPSC
12352005
Hazard Statement
H302, H315
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cibenzoline.html
Concentration
10mM
Purity
95.08
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C1(C2CC2(C3=CC=CC=C3)C4=CC=CC=C4)=NCCN1
Molecular Formula
C18H18N2
Molecular Weight
262.36
Precautions
H302, H315
References & Citations
[1]Mukai E, et al. The antiarrhythmic agent cibenzoline inhibits KATP channels by binding to Kir6.2. Biochem Biophys Res Commun. 1998;251 (2) :477-481.|[2]Hamada M, et al. Class Ia antiarrhythmic drug cibenzoline: a new approach to the medical treatment of hypertrophic obstructive cardiomyopathy. Circulation. 1997;96 (5) :1520-1524.|[3]Satoh H. Comparative actions of cibenzoline and disopyramide on I (Kr) and I (Ks) currents in rat sino-atrial nodal cells. Eur J Pharmacol. 2000 Oct 27;407 (1-2) :123-9.|[4]Takahashi Y, et al. Pharmacodynamics of cibenzoline-induced hypoglycemia in rats. Drug Metab Pharmacokinet. 2011 Jun;26 (3) :242-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 4

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