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USP1-IN-9

CAT: 0804-HY-162633Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162633Size:1 Each
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Description
USP1-IN-9 (Compound 1m) is reversible and noncompetitive ubiquitin-specific proteases (USP1) inhibitors with an IC50 of 8.8 nM, which is designed and synthesized to pyrido[2,3-d]pyrimidin-7 (8H) -one derivative based on the disclosed structure of ML323 and KSQ-4279 (HY-145471). USP1-IN-9 displays excellent USP1/UAF inhibition and exhibits strong antiproliferation effect in breast cancer cells. USP1-IN-9 can generate enhanced cell killing with PARP inhibitor olaparib (HY-10162) in olaparib-resistant MDA-MB-436/OP cells, which is promising for research in the field of cancer[1].
CAS Number
2925548-22-5
UNSPSC
12352005
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/usp1-in-9.html
Smiles
O=C1C=CC2=CN=C(C3=C(C4CC4)N=CN=C3OC)N=C2N1CC5=CC=C(C6=NC(C(F)(F)F)=CN6C(C)C)C=C5
Molecular Formula
C29H26F3N7O2
Molecular Weight
561.56
References & Citations
[1][1] Li H, et al. Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidin-7 (8H) -one derivatives as potent USP1 inhibitors[j]. Eur J Med Chem. 2024 Jun 14;275:116568.https://pubmed.ncbi.nlm.nih.gov/38889606/|[2][1] Li H, et al. Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidin-7 (8H) -one derivatives as potent USP1 inhibitors[j]. Eur J Med Chem. 2024 Jun 14;275:116568.https://pubmed.ncbi.nlm.nih.gov/38889606/|[3][1] Li H, et al. Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidin-7 (8H) -one derivatives as potent USP1 inhibitors[J]. Eur J Med Chem. 2024 Jun 14;275:116568.https://pubmed.ncbi.nlm.nih.gov/38889606/|[4]Li H, et al. Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidin-7 (8H) -one derivatives as potent USP1 inhibitors[J]. Eur J Med Chem. 2024 Jun 14;275:116568.|[5]Li H, et al. Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidin-7 (8H) -one derivatives as potent USP1 inhibitors[J]. Eur J Med Chem. 2024 Jun 14;275:116568.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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