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USP1-IN-8

CAT: 0804-HY-161447Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-161447Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
USP1-IN-8 (Compound 16) is an inhibitor for ubiquitin specific peptidase 1 (USP1) and its cofactor UAF1, with IC50 ≤50 nM. USP1-IN-8 inhibits proliferation of MDA-MB-436 with IC50 ≤50 nM[1].
CAS Number
3033480-77-9
UNSPSC
12352005
Target
Deubiquitinase
Type
Isotope-Labeled Compounds
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
O=C1N(CC2=CC=C(C3=NC(C(F)(F)F)=CN3C(C)C)C=C2)C4=C(F)C(C5=C(OC)N=CN=C5C6CC6)=NC=C4N1C([2H])([2H])[2H]
Molecular Formula
C29H24D3F4N7O2
Molecular Weight
584.58
References & Citations
[1]Liu BM, et al., Carbonyl fused heterocyclic derivative used as ubiquitin-specific protease inhibitor. WO2024061213A1.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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