USP1-IN-9

CAT: 0931-MF-0117668-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0117668-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
DUB
Related Pathways
Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||Ubiquitination
Bioactivity
USP1-IN-9 (Compound 1m) is a reversible and non-competitive inhibitor of ubiquitin-specific protease (USP1) with an IC50 value of 8.8 nM. It is synthesized based on the structures of ML323 and KSQ-4279 as a pyrido[2,3-d]pyrimidin-7 (8H) -one derivative. USP1-IN-9 exhibits excellent inhibition of USP1/UAF and demonstrates strong antiproliferative effects on breast cancer cells. When combined with the PARP inhibitor olaparib, USP1-IN-9 enhances the cytotoxic effect on MDA-MB-436/OP cells. USP1-IN-9 holds potential for research in the field of cancer.
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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