LASSBio-873

• Description:

  LASSBio-873 is an orally active muscarinic cholinergic receptor (mAChR) agonist that crosses the blood-brain barrier. LASSBio-873 has potent analgesic effects on acute and inflammatory pain. The analgesic effect of LASSBio-873 can be inhibited by intrathecal injection of the M2 receptor antagonist methoctramine[1].

• UNSPSC:

  12352005

• Target:

  MAChR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/lassbio-873.html

• Purity:

  99.82

• Solubility:

  DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C1N(C2=CC=C([N+]([O-])=O)C=C2)C(C3=C1C=NC4=C3C(C)=NN4C5=CC=CC=C5)=O

• Molecular Formula:

  C21H13N5O4

• Molecular Weight:

  399.36

• References & Citations:

  [1]Mendes TC, et al. Antihyperalgesic effects of a novel muscarinic agonist (LASSBio-873) in spinal nerve ligation in rats. Clin Exp Pharmacol Physiol. 2013 Jul;40 (7) :404-11.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [873694-54-3]