ζ-Stat

• Description :

  ζ-Stat (NSC37044) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro[1][2].

• Product Name Alternative :

  NSC37044

• UNSPSC :

  12352005

• Target :

  Apoptosis; PKC

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Epigenetics; TGF-beta/Smad

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ζ-stat.html

• Concentration :

  10mM

• Purity :

  98.98

• Solubility :

  H2O : 62.5 mg/mL (ultrasonic)

• Smiles :

  O=S(C1=C2C(O)=CC(S(=O)(O)=O)=CC2=CC(S(=O)(O)=O)=C1)(O)=O

• Molecular Formula :

  C10H8O10S3

• Molecular Weight :

  384.36

• References & Citations :

  [1]Ratnayake WS, et, al. Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors. Cell Adh Migr. 2018; 12 (5) :447-463.|[2]Islam SMA, et, al. Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells. Biomed Pharmacother. 2020 Jan; 121:109665.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PKCζ

• CAS Number :

  [3316-02-7]