ζ-Stat

• Product Name Alternative:

  NSC37044

• UNSPSC Description:

  ζ-Stat (NSC37044) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro[1][2].

• Target Antigen:

  Apoptosis; PKC

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Epigenetics;TGF-beta/Smad

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ζ-stat.html

• Purity:

  95.05

• Solubility:

  H2O : 62.5 mg/mL (ultrasonic)

• Smiles:

  O=S(C1=C2C(O)=CC(S(=O)(O)=O)=CC2=CC(S(=O)(O)=O)=C1)(O)=O

• Molecular Weight:

  384.36

• References & Citations:

  [1]Ratnayake WS, et, al. Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors. Cell Adh Migr. 2018; 12(5):447-463.|[2]Islam SMA, et, al. Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells. Biomed Pharmacother. 2020 Jan; 121:109665.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  3316-02-7