Ac-Exatecan

• Description:

  Ac-Exatecan is acetylation-modified Exatecan (HY-13631) . Exatecan is a common toxin component in ADC preparation (ADC cytotoxin) and an inhibitor of DNA topoisomerase I (IC50 = 2.2 μM) . Exatecan has antitumor activity. Exatecan can be used as a payload for ADC. Exatecan is effective against P-glycoprotein mediated multi-drug resistant cells[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  ADC Payload; Topoisomerase

• Type:

  Reference compound

• Related Pathways:

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ac-exatecan.html

• Concentration:

  10mM

• Purity:

  99.02

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (OC1) [C@@] (CC) (O) C2=C1C (N3C (C4=NC5=CC (F) =C (C) C6=C5C ([C@@H] (NC (C) =O) CC6) =C4C3) =C2) =O

• Molecular Formula:

  C26H24FN3O5

• Molecular Weight:

  477.48

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86 (8) :776-82.|[2]Nakada, T., et al., (2016) . Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads. Bioorganic & medicinal chemistry letters, 26 (6), 1542–1545.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Camptothecins

• CAS Number:

  2922852-48-8