Products for Research Use Only
RegisterLogin

Ac-Exatecan

CAT: 0804-HY-79490-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-79490-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Ac-Exatecan is acetylation-modified Exatecan. Exatecan is a common toxin component in ADC preparation (ADC cytotoxin) and an inhibitor of DNA topoisomerase I (IC50 = 2.2 μM). Exatecan has antitumor activity. Exatecan can be used as a payload for ADC. Exatecan is effective against P-glycoprotein mediated multi-drug resistant cells[1][2].
CAS Number
2922852-48-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ADC Payload; Topoisomerase
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ac-exatecan.html
Concentration
10mM
Purity
99.02
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OC1)[C@@](CC)(O)C2=C1C(N3C(C4=NC5=CC(F)=C(C)C6=C5C([C@@H](NC(C)=O)CC6)=C4C3)=C2)=O
Molecular Formula
C26H24FN3O5
Molecular Weight
477.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86 (8) :776-82.|[2]Nakada, T., et al., (2016) . Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads. Bioorganic & medicinal chemistry letters, 26 (6), 1542–1545.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Camptothecins

Related Products

CatalogName
HY-13631-01Exatecan
HY-13631A-01Exatecan (mesylate)
HY-13631R-01Exatecan (Standard)
HY-156617-01Cyclopropaneacetamide-Exatecan
HY-160015-01CB07-Exatecan
HY-128994-01GGFG-Exatecan
HY-13631N(9R) -Exatecan
HY-176976Exatecan-mpGNNG
HY-159783-01Mal-Exatecan
HY-153185-01Decyclohexanamine-Exatecan

Alternative Products

CatalogName
T77901-01Ac-Exatecan
DE2061Ac-Exatecan-D5
T11249-01Exatecan
BA2357-1Decyclohexanamine-Exatecan
CS-O-47297Exatecan Hydroxyacid
FE72401-01Exatecan mesylate
A11231-500Exatecan 500mg

Popular Products