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GGFG-Exatecan

CAT: 0804-HY-128994-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-128994-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GGFG-Exatecan is a synthetic intermediate for drug-linker conjugates used in antibody-drug conjugates (ADCs). GGFG-Exatecan consists of a glycyl-glycyl-phenylalanyl-glycine (GGFG) tetrapeptide linker and a DNA topoisomerase I inhibitor Exatecan. GGFG-Exatecan can be used for the study of cancer[1].
CAS Number
223537-10-8
UNSPSC
12352005
Target
Drug Intermediate
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(NCC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=O)=O)=O
Molecular Formula
C39H40FN7O8
Molecular Weight
753.78
References & Citations
[1]Nakada T, et al. Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads. Bioorg Med Chem Lett. 2016 Mar 15;26 (6) :1542-1545.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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