GGFG-Exatecan

• Description:

  GGFG-Exatecan is a synthetic intermediate for drug-linker conjugates used in antibody-drug conjugates (ADCs) . GGFG-Exatecan consists of a glycyl-glycyl-phenylalanyl-glycine (GGFG) tetrapeptide linker and a DNA topoisomerase I inhibitor Exatecan (HY-13631) . GGFG-Exatecan can be used for the study of cancer[1].

• UNSPSC:

  12352005

• Target:

  Drug Intermediate

• Related Pathways:

  Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Smiles:

  NCC (NCC (N[C@@H] (CC1=CC=CC=C1) C (NCC (N[C@@H]2C3=C4C (C (N5C4) =CC ([C@] (O) (C (OC6) =O) CC) =C6C5=O) =NC7=CC (F) =C (C) C (CC2) =C73) =O) =O) =O) =O

• Molecular Formula:

  C39H40FN7O8

• Molecular Weight:

  753.78

• References & Citations:

  [1]Nakada T, et al. Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads. Bioorg Med Chem Lett. 2016 Mar 15;26 (6) :1542-1545.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  223537-10-8