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Exatecan (Standard)

CAT: 0804-HY-13631R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13631R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Exatecan (Standard) is the analytical standard of Exatecan. This product is intended for research and analytical applications. Exatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research.
CAS Number
171335-80-1
Product Name Alternative
DX-8951 (Standard)
UNSPSC
12352005
Hazard Statement
H300, H340, H360
Target
ADC Payload; Reference Standards; Topoisomerase
Type
Reference Standards
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/exatecan-standard.html
Purity
99.89
Smiles
O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C5C6=C(CC[C@@H]5N)C(C)=C(F)C=C6N=C4C3=C2)=O
Molecular Formula
C24H22FN3O4
Molecular Weight
435.45
Precautions
H300, H340, H360
References & Citations
[1]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86 (8) :776-82.|[2]Sun FX, et al. Efficacy of camptothecin analog DX-8951f (Exatecan Mesylate) on human pancreatic cancer in an orthotopic metastatic model. Cancer Res. 2003 Jan 1;63 (1) :80-5.|[3]Joto N, et al. DX-8951f, a water-soluble camptothecin analog, exhibits potent antitumor activity against a human lung cancer cell line and its SN-38-resistant variant. Int J Cancer. 1997 Aug 7;72 (4) :680-6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, sealed and dry storage, away from light and moisture
Scientific Category
Reference Standards
Clinical Information
No Development Reported

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