Mal-Exatecan

• Description :

  Mal-Exatecan is a Mal (Maleimide) modified Exatecan (HY-13631), a DNA topoisomerase I (topoisomerase I) inhibitor[1].

• UNSPSC :

  12352203

• Target :

  ADC Payload; Topoisomerase

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Purity :

  99.39

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(C=CC1=O)N1CCCCCC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O

• Molecular Formula :

  C34H33FN4O7

• Molecular Weight :

  628.65

• References & Citations :

  [1]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86 (8) :776-82.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• CAS Number :

  [3028213-52-4]