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Antitumor agent-127

CAT: 0804-HY-161096-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-161096-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Antitumor agent-127 (compound 1) is a parent macrocyclic peptide. Antitumor agent-127 displays nanomolar cell-based binding to ROR1 and relatively good internalization in 786-O and MDA-MB-231 tumor cell lines[1].
CAS Number
9007-83-4
UNSPSC
12352209
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-127.html
Purity
99.09
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@H](C(NCC(N)=O)=O)CSCC(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC2=CC=C(O)C=C2)C(N[C@H](C(NCC(N[C@@H](CC3=CNC4=C3C=CC=C4)C(N[C@H]5CC6=CC=C(O)C=C6)=O)=O)=O)CO)=O)=O)C(C)C)=O)=O)=O)CC7=CC=CC=C7)=O)[C@H](CC(C)C)NC([C@H](CC8=CC=CC=C8)N(C)C5=O)=O
Molecular Formula
C86H107N15O18S
Molecular Weight
1670.92
References & Citations
[1]Qiao JX, et al. Exploration of macrocyclic peptide binders to the extracellular CRD domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1) . Bioorg Med Chem Lett. 2023 Dec 13;98:129589.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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