VHL-SF2

• Description:

  VHL-SF2 is a VHL ligand, and can be used for synthesis of PROTACs[1]

• UNSPSC:

  12352005

• Target:

  Ligands for E3 Ligase

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/vhl-sf2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C)[C@H](C1=CC(C)=NO1)C(N2[C@@H](C[C@H](C2)S(F)(=O)=O)C(N[C@H](C3=CC=C(C4=C(N=CS4)C)C=C3)CC(OC(C)(C)C)=O)=O)=O

• Molecular Formula:

  C31H39FN4O7S2

• Molecular Weight:

  662.79

• References & Citations:

  [1]Shah RR, et al. Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs. J Med Chem. 2024 Mar 28;67 (6) :4641-4654.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Von Hippel-Lindau (VHL)

• CAS Number:

  [3050690-24-6]