VHL-SF2

• Description :

  VHL-SF2 is a VHL ligand, and can be used for synthesis of PROTACs[1]

• CAS Number :

  [3050690-24-6]

• UNSPSC :

  12352005

• Target :

  Ligands for E3 Ligase

• Type :

  Reference compound

• Related Pathways :

  PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/vhl-sf2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C)[C@H](C1=CC(C)=NO1)C(N2[C@@H](C[C@H](C2)S(F)(=O)=O)C(N[C@H](C3=CC=C(C4=C(N=CS4)C)C=C3)CC(OC(C)(C)C)=O)=O)=O

• Molecular Formula :

  C31H39FN4O7S2

• Molecular Weight :

  662.79

• References & Citations :

  [1]Shah RR, et al. Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs. J Med Chem. 2024 Mar 28;67 (6) :4641-4654.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Von Hippel-Lindau (VHL)