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STAT3-IN-36

CAT: 0804-HY-168519Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168519Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
STAT3-IN-36 (compound 11g) is a triple-target inhibitor targeting LRPPRC, STAT3, and CDK1 with anticancer activity. STAT3-IN-36 binds to LRPPRC, STAT3, and CDK1, exerting a stronger anticancer effect than TMF or Capecitabine (HY-B0016). STAT3-IN-36 inhibits HGC27 cells with IC50 1.8 μM.[1].
CAS Number
3055766-74-7
UNSPSC
12352211
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/stat3-in-36.html
Smiles
O=S(C1=C(OC)C=C(OC)C2=C1OC(C3=CC=C(OC)C(S(=O)(NC4=CC=C(F)C=C4)=O)=C3)=CC2=O)(NC5=CC=C(F)C=C5)=O
Molecular Formula
C30H24F2N2O9S2
Molecular Weight
658.65
References & Citations
[1]Wu R, et al. Design, synthesis, and biological evaluation of novel 5,7,4'-trimethoxyflavone sulfonamide-based derivatives as highly potent inhibitors of LRPPRC/STAT3/CDK1. Bioorg Chem. 2024 Dec;153:107878.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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