STAT3-IN-36

STAT3-IN-36

• CAS Number: 3055766-74-7
• UNSPSC Description: STAT3-IN-36 (compound 11g) is a triple-target inhibitor targeting LRPPRC, STAT3, and CDK1 with anticancer activity. STAT3-IN-36 binds to LRPPRC, STAT3, and CDK1, exerting a stronger anticancer effect than TMF (HY-N6818) or Capecitabine (HY-B0016). STAT3-IN-36 inhibits HGC27 cells with IC50 1.8 μM.[1].
• Target Antigen: STAT
• Type: Reference compound
• Related Pathways: JAK/STAT Signaling;Stem Cell/Wnt
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/stat3-in-36.html
• Smiles: O=S(C1=C(OC)C=C(OC)C2=C1OC(C3=CC=C(OC)C(S(=O)(NC4=CC=C(F)C=C4)=O)=C3)=CC2=O)(NC5=CC=C(F)C=C5)=O
• Molecular Weight: 658.65
• References & Citations: [1]Wu R, et al. Design, synthesis, and biological evaluation of novel 5,7,4'-trimethoxyflavone sulfonamide-based derivatives as highly potent inhibitors of LRPPRC/STAT3/CDK1. Bioorg Chem. 2024 Dec;153:107878.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported