LSD1-IN-35

• UNSPSC Description:

  LSD1-IN-35 (Compound Z-1) is a selective LSD1 Inhibitor (IC50: 108 nM). LSD1-IN-35 inhibits the demethylation on H3K4me1/2. LSD1-IN-35 is an immunomodulator. LSD1-IN-35 promotes response of gastric cancer cells to T-cell killing effect by decreasing PD-L1 expression and further attenuates the PD-1/PD-L1 interaction[1].

• Target Antigen:

  Histone Demethylase; PD-1/PD-L1

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;Immunology/Inflammation

• Field of Research:

  Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/lsd1-in-35.html

• Smiles:

  O=S(C1=CC=C(C2=NC3=CC=CC=C3C(NC4=CC=C(C=C4)N(CC)CC)=N2)C=C1)(C)=O

• Molecular Weight:

  446.56

• References & Citations:

  [1]Bo Wang, et al. Discovery of 2-Aryl-4-aminoquinazolin-Based LSD1 Inhibitors to Activate Immune Response in Gastric Cancer. Med. Chem. 2024, 67, 18, 16165-16184.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2992690-04-5