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LSD1-IN-35

CAT: 0804-HY-168086Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168086Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LSD1-IN-35 (Compound Z-1) is a selective LSD1 Inhibitor (IC50: 108 nM) . LSD1-IN-35 inhibits the demethylation on H3K4me1/2. LSD1-IN-35 is an immunomodulator. LSD1-IN-35 promotes response of gastric cancer cells to T-cell killing effect by decreasing PD-L1 expression and further attenuates the PD-1/PD-L1 interaction[1].
CAS Number
2992690-04-5
UNSPSC
12352005
Target
Histone Demethylase; PD-1/PD-L1
Type
Reference compound
Related Pathways
Epigenetics; Immunology/Inflammation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lsd1-in-35.html
Smiles
O=S(C1=CC=C(C2=NC3=CC=CC=C3C(NC4=CC=C(C=C4)N(CC)CC)=N2)C=C1)(C)=O
Molecular Formula
C25H26N4O2S
Molecular Weight
446.56
References & Citations
[1]Bo Wang, et al. Discovery of 2-Aryl-4-aminoquinazolin-Based LSD1 Inhibitors to Activate Immune Response in Gastric Cancer. Med. Chem. 2024, 67, 18, 16165-16184.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM1/LSD1

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