LSD1-IN-40

• Description:

  LSD1-IN-40 (Compound 9e) is a potent LSD1 inhibitor, with an IC50 of 9.85 nM. LSD1-IN-40 exhibits exceptional selectivity for LSD1 over both MAOs and hERG. LSD1-IN-40 exhibits significant inhibitory activity against leukemia cells (MV-4-11, HL-60, and THP-1 cells) . LSD1-IN-40 can induce apoptosis in MV-4-11 cells. LSD1-IN-40 has the potential for the research of acute myeloid leukemia[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Histone Demethylase

• Related Pathways:

  Apoptosis; Epigenetics

• Field of Research:

  Cancer

• Smiles:

  O=S (C1=CC=CC=C1) (N2C (C=CC (N3C=C (CN[C@@H]4C[C@H]4C5=CC=C (F) C (F) =C5) N=N3) =C6) =C6C=N2) =O

• Molecular Formula:

  C25H20F2N6O2S

• Molecular Weight:

  506.53

• References & Citations:

  [1]Huang MJ, et, al. Discovery of novel tranylcypromine-indazole-based derivatives as LSD1 inhibitors for acute myeloid leukemia treatment. Eur J Med Chem. 2025 May 5:289:117438.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported