LSD1-IN-40

• Description :

  LSD1-IN-40 (Compound 9e) is a potent LSD1 inhibitor, with an IC50 of 9.85 nM. LSD1-IN-40 exhibits exceptional selectivity for LSD1 over both MAOs and hERG. LSD1-IN-40 exhibits significant inhibitory activity against leukemia cells (MV-4-11, HL-60, and THP-1 cells) . LSD1-IN-40 can induce apoptosis in MV-4-11 cells. LSD1-IN-40 has the potential for the research of acute myeloid leukemia[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Histone Demethylase

• Related Pathways :

  Apoptosis; Epigenetics

• Field of Research :

  Cancer

• Smiles :

  O=S(C1=CC=CC=C1)(N2C(C=CC(N3C=C(CN[C@@H]4C[C@H]4C5=CC=C(F)C(F)=C5)N=N3)=C6)=C6C=N2)=O

• Molecular Formula :

  C25H20F2N6O2S

• Molecular Weight :

  506.53

• References & Citations :

  [1]Huang MJ, et, al. Discovery of novel tranylcypromine-indazole-based derivatives as LSD1 inhibitors for acute myeloid leukemia treatment. Eur J Med Chem. 2025 May 5:289:117438.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported