LSD1-IN-14

• Description:

  LSD1-IN-14 is a potent and selective LSD1 inhibitor (IC50=0.89 μM) . LSD1-IN-14 can significantly inhibit the proliferation of A549 and THP-1 cells and induce the apoptosis of tumor cells[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Histone Demethylase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/lsd1-in-14.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CN(CCN(C1=CC=C(C=C1)NC2=NC=C(C=N2)C3=CC=C(C=C3)F)C)C

• Molecular Formula:

  C21H24FN5

• Molecular Weight:

  365.45

• References & Citations:

  [1]Wang X, et al. Design, synthesis and biological evaluation of 2-aminopyrimidine-based LSD1 inhibitors. Bioorg Chem. 2022;121:105699.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  KDM1/LSD1

• CAS Number:

  [2698340-11-1]