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LSD1-IN-35

CAT: 0931-T200691-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T200691-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2992690-04-5
Target
Histone Demethylase, PD-1/PD-L1
Related Pathways
Immunology/Inflammation, Apoptosis, Chromatin/Epigenetic, Cell Cycle/Checkpoint
Bioactivity
LSD1-IN-35 (Compound Z-1) is a selective inhibitor of LSD1, exhibiting an IC50 of 108 nM. This compound inhibits the demethylation of H3K4me1/2 and acts as an immunomodulator. Additionally, LSD1-IN-35 enhances the responsiveness of gastric cancer cells to T-cell killing by reducing PD-L1 expression, thereby weakening the PD-1/PD-L1 interaction.
Smiles
O=S(=O)(C=1C=CC(=CC1)C=2N=C3C=CC=CC3=C(N2)NC4=CC=C(C=C4)N(CC)CC)C
Molecular Formula
C25H26N4O2S
Molecular Weight
446.57
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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