Antitumor agent-149

• Target:

  Apoptosis

• Related Pathways:

  Apoptosis

• Bioactivity:

  Antitumor agent-149 (Compound 3), an analogue of Echinomycin, inhibits HIF-1?-mediated transcription, induces cancer cell apoptosis, and suppresses tumor growth in the SW620 xenograft mice model [1].

• Smiles:

  C(N[C@@H]1COC(=O)[C@H](C(C)C)N(C)C(=O)[C@@]2(CSC[C@](N(C)C(=O)[C@H](C)NC1=O)(C(=O)N(C)[C@@H](C(C)C)C(=O)OC[C@@H](NC(=O)C3=NC4=C(C=C3O)C=CC=C4)C(=O)N[C@@H](C)C(=O)N2C)[H])[H])(=O)C5=NC6=C(C=C5O)C=CC=C6

• Molecular Formula:

  C52H64N10O14S

• Molecular Weight:

  1085.19

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2368983-54-2