PROTAC SMARCA2 degrader-21

PROTAC SMARCA2 degrader-21

• CAS Number: 2891464-61-0
• UNSPSC Description: PROTAC SMARCA2 degrader-21 (Compound I-5) is a PROTAC degrader for SMARCA, that degrades SMARCA2 with a DC50 of 10-50 nM in A549 cell, and degrades SMARCA2 and SMARCA4 in MV411 with DC50 of 100 nM, respectively[1].
• Target Antigen: Epigenetic Reader Domain; PROTACs
• Type: Reference compound
• Related Pathways: Epigenetics;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-smarca2-degrader-21.html
• Smiles: CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(C4CC5(CC(C5)N6CCC(CC6)C7=NC(N8CCN9C%10=CC(C%11=C(C=CC=C%11)O)=NN=C%10NC[C@H]9C8)=NC=C7)C4)=O)=O)O)=O
• Molecular Weight: 995.24
• References & Citations: [1]Zhang Y, et al., Smarca degraders and uses thereof. WO2023278402.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported