PROTAC SMARCA2 degrader-19

PROTAC SMARCA2 degrader-19

• CAS Number: 2567913-00-0
• UNSPSC Description: PROTAC SMARCA2 degrader-19 (Compound 46) is a PROTAC degrader for SMARCA2, that degrades SMARCA2 in cell A549 and MV411 with a DC50 SMARCA4 in cell MV411 with a DC50 > 1000 nM[1].
• Target Antigen: Epigenetic Reader Domain; PROTACs
• Type: Reference compound
• Related Pathways: Epigenetics;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-smarca2-degrader-19.html
• Smiles: OC1=C(C=CC=C1)C2=NN=C3NC=C(C4CCN(C5=NC=C([C@@H]6CC[C@H](CC6)C(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C9=C(C)N=CS9)C=C8)=O)=O)=O)C=N5)CC4)C3=C2
• Molecular Weight: 911.12
• References & Citations: [1]Ji, et al., Smarca degraders and uses thereof. WO2020251972.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported