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PROTAC SMARCA2 degrader-13

CAT: 0804-HY-163865Size: 1 EachDry Ice: NoHazardous: No
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Description
SMARCA2 degrader-2 (compound I-322) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 90 after 24 h of treatment[1].
CAS Number
2568276-72-0
UNSPSC
12352005
Target
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-smarca2-degrader-13.html
Smiles
O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NC4CCC(CC4)N5CCC(CC5)N6N=CC(C7=C(N)N=NC(C8=C(O)C=CC=C8)=C7)=C6)=CC=C3)=O)=O
Molecular Formula
C37H39N9O5
Molecular Weight
689.76
References & Citations
[1]Preparation of heterocyclic compounds as SMARCA degraders and uses thereof. World Intellectual Property Organization, WO2020251971 A1 2020-12-17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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