PROTAC SMARCA2 degrader-28

PROTAC SMARCA2 degrader-28

• CAS Number: 2641510-88-3
• UNSPSC Description: PROTAC SMARCA2 degrader-28 (Compound 158) is a PROTAC degrader for SMARCA2, that degrades SMARCA2 with a DC50 of 3 nM in HiBiT A549 cells. (Pink: Ligand for target protein (HY-168237); Black: Linker (HY-168238); Blue: Ligand for E3 ligase (HY-W087383))[1]
• Target Antigen: Epigenetic Reader Domain; PROTACs
• Type: Reference compound
• Related Pathways: Epigenetics;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-smarca2-degrader-28.html
• Smiles: OC1=C(C2=CC(N3CC4N(C5=CC=CC(CN6CCN(C(C7CCN(C8=CC(C(N(C9CCC(NC9=O)=O)C%10=O)=O)=C%10C=C8)CC7)=O)CC6)=C5)C(CC4)C3)=C(N)N=N2)C=C(F)C=C1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
• Molecular Weight: 1084.99
• References & Citations: [1]Duplessis M, et al., Bifunctional compounds for the treatment of cancer. WO2021083949.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported