PROTAC SMARCA2 degrader-31

PROTAC SMARCA2 degrader-31

• CAS Number: 2380274-45-1
• UNSPSC Description: PROTAC SMARCA2-degrader-36 (compound 38) is a SMARCA2 degrader and can reach the the degradation rate of 99 % at the 100 nM in H929 cells. PROTAC SMARCA2-degrader-36 shows anti-proliferative activity and can be used for study of cancer(Structure Note: PINK SMARCA2 ligand HY-44012; Blue, VHL ligand (HY-112078); Black, linker HY-W014125)[1].
• Target Antigen: Epigenetic Reader Domain; PROTACs
• Type: Reference compound
• Related Pathways: Epigenetics;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-smarca2-degrader-31.html
• Smiles: OC1=C(C2=CC(N3CCN(C(CCCCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)C[C@@H](O)C4)=O)=O)=O)CC3)=C(N)N=N2)C=CC=C1
• Molecular Weight: 896.15
• References & Citations: [1]Sanjita SASMAL, et al. Pyridazine derivatives as smarca2/4 degraders. WO2019207538 A1. 2024-03-19.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported