PROTAC SMARCA2 degrader-10

• UNSPSC Description:

  PROTAC SMARCA2 degrader-10 (compound I-507) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 90 after 24 h of treatment[1].

• Target Antigen:

  PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-smarca2-degrader-10.html

• Smiles:

  O=C(C1=CC=C(C2=CC=C(C=C2)CN3CCC(CC3)CN4C=C(C5=C(N)N=NC(C6=C(C=CC=C6)O)=C5)C=N4)C=C1)N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C9=C(N=CS9)C)C=C8)=O)=O

• Molecular Weight:

  973.19

• References & Citations:

  [1]Preparation of heterocyclic compounds as SMARCA degraders and uses thereof. World Intellectual Property Organization, WO2020251971 A1 2020-12-17.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2568279-34-3