PROTAC SMARCA2 degrader-10

PROTAC SMARCA2 degrader-10

• CAS Number: 2568279-34-3
• UNSPSC Description: PROTAC SMARCA2 degrader-10 (compound I-507) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 90 after 24 h of treatment[1].
• Target Antigen: PROTACs
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-smarca2-degrader-10.html
• Smiles: O=C(C1=CC=C(C2=CC=C(C=C2)CN3CCC(CC3)CN4C=C(C5=C(N)N=NC(C6=C(C=CC=C6)O)=C5)C=N4)C=C1)N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C9=C(N=CS9)C)C=C8)=O)=O
• Molecular Weight: 973.19
• References & Citations: [1]Preparation of heterocyclic compounds as SMARCA degraders and uses thereof. World Intellectual Property Organization, WO2020251971 A1 2020-12-17.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported