DPP-4-IN-18

• Description:

  DPP-4-IN-18 (Sitagliptin impurity 3) (Compound 4) impurity 3 is a potent, selective and orally active DPP-4 inhibitor with an IC50 of 27 nM. DPP-4-IN-18 can effectively prevent DPP-4 from degrading glucagon-like peptide 1 (GLP-1), thereby increasing the level of active GLP-1. DPP-4-IN-18 can be used for the research of type 2 diabetes[1].

• Product Name Alternative:

  Sitagliptin impurity 3

• UNSPSC:

  12352005

• Hazard Statement:

  H319-H373

• Target:

  Dipeptidyl Peptidase

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Metabolic Disease

• Smiles:

  O=C (N1CC2=NN=C (C (F) (F) F) N2CC1) C[C@H] (N) CC3=CC (F) =CC=C3F

• Molecular Formula:

  C16H16F5N5O

• Molecular Weight:

  389.32

• Precautions:

  P260-P264-P280-P305+P351+P338-P501

• References & Citations:

  [1]Thornberry NA, et al. Discovery of JANUVIA (Sitagliptin), a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Curr Top Med Chem. 2007;7 (6) :557-68.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound2

• Clinical Information:

  No Development Reported

• Isoform:

  DPP-4

• CAS Number:

  486460-31-5