DPP-4-IN-18

• Description :

  DPP-4-IN-18 (Sitagliptin impurity 3) (Compound 4) impurity 3 is a potent, selective and orally active DPP-4 inhibitor with an IC50 of 27 nM. DPP-4-IN-18 can effectively prevent DPP-4 from degrading glucagon-like peptide 1 (GLP-1), thereby increasing the level of active GLP-1. DPP-4-IN-18 can be used for the research of type 2 diabetes[1].

• Product Name Alternative :

  Sitagliptin impurity 3

• UNSPSC :

  12352005

• Hazard Statement :

  H319-H373

• Target :

  Dipeptidyl Peptidase

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Metabolic Disease

• Smiles :

  O=C(N1CC2=NN=C(C(F)(F)F)N2CC1)C[C@H](N)CC3=CC(F)=CC=C3F

• Molecular Formula :

  C16H16F5N5O

• Molecular Weight :

  389.32

• Precautions :

  P260-P264-P280-P305+P351+P338-P501

• References & Citations :

  [1]Thornberry NA, et al. Discovery of JANUVIA (Sitagliptin), a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Curr Top Med Chem. 2007;7 (6) :557-68.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound2

• Clinical Information :

  No Development Reported

• Isoform :

  DPP-4

• CAS Number :

  [486460-31-5]