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Antitumor agent-163

CAT: 0013-GTR19262514-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19262514-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Antitumor agent-163 (Compound 3) serves as a photosensitizer in molecular-targeted photodynamic therapy (MT-PDT) aimed at carbonic anhydrase IX (CAIX) . Under illumination at 540 nm, Antitumor agent-163 inactivates CAIX protein through singlet oxygen generation without affecting internal standard proteins such as α-tubulin, β-actin, and proliferating cell nuclear antigen (PCNA) . It induces cell membrane damage and reduces cell viability with IC50 values of 0.2 μM for A549 and 0.05 μM for U87MG. Furthermore, Antitumor agent-163 demonstrates antitumor activity in mouse models.
Field of Research
Metabolism Research
Molecular Formula
C27H32BF2I2N5O4S
Storage Conditions
-20°C
Notes
For research use only.

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