TMX-2172

CAT: 0931-T202515-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T202515-01Size:10 mg
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CAS Number
2488892-09-5
Target
CDK|||PROTACs
Related Pathways
PROTAC|||Cell Cycle/Checkpoint
Bioactivity
TMX-2172 is a heterobifunctional CDK2 degrader, selectively degrading CDK2 and CDK5, with minimal effects on CDK1, transcriptional CDKs (CDK7 and CDK9), and cell cycle CDKs (CDK4 and CDK6) . In ovarian cancer cells (OVCAR8), its anti-proliferative activity is dependent on CDK2 degradation and is linked to high expression of cyclin E1 (CCNE1), which acts as a regulatory subunit of CDK2. As a lead compound for further development, TMX-2172 demonstrates that CDK2 degradation could be a potentially effective strategy for treating ovarian and other cancers with elevated CCNE1 expression.
Smiles
O=C(N)C=1C(F)=CC=CC1NC2=NC(=NC=C2Br)NC3=CC=C(C=C3C)S(=O)(=O)NCCOCCOCCOCCOCCNC4=CC=CC=5C(=O)N(C(=O)C45)C6C(=O)NC(=O)CC6
Molecular Formula
C41H45BrFN9O11S
Molecular Weight
970.82
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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