RegisterLogin

TDO-IN-1

CAT: 0804-HY-151425-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-151425-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
TDO-IN-1 is an orally active and selective inhibitor of tryptophan 2,3-dioxygenase (TDO), shows excellent selectivity over indoleamine-2,3-dioxygenase (IDO), with an IC50 value of 0.62 μM (IDO) . TDO-IN-1 reverse the local immune tolerance of tumor tissue to inhibit tumor growth in vivo[1].
CAS Number
[2490672-92-7]
UNSPSC
12352005
Target
Indoleamine 2,3-Dioxygenase (IDO)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tdo-in-1.html
Purity
99.07
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(C1=CC2=C(C(NCC3=CC=C(C)C=C3[N+]([O-])=O)=C1)C=NN2)(F)F
Molecular Formula
C16H13F3N4O2
Molecular Weight
350.30
References & Citations
[1]Huo C, et al. 4,6-Disubstituted-1H-Indazole-4-Amine derivatives with immune-chemotherapy effect and in vivo antitumor activity. Eur J Med Chem. 2022 Nov 5;241:114625.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-172874TDO-IN-2
HY-146673IDO1/TDO-IN-2
HY-177086-01IDO1/TDO-IN-9
HY-149411IDO1/TDO-IN-6
HY-146674IDO1/TDO-IN-3
HY-173513IDO1/TDO-IN-8
HY-178470IDO1/TDO-IN-10
HY-162962IDO1/TDO-IN-7
HY-151108-01IDO1/TDO-IN-4
HY-170322TDO2-IN-1

Alternative Products

CatalogName
T61202-01TDO-IN-1
MBS5804089IDO1/TDO-IN-1
MBS5766840IDO/TDO-IN-1
YP-W39319-01Rat TDO (TDO) ELISA Kit
A18566-25IDO/TDO-IN-1 25mg
A18566-5IDO/TDO-IN-1 5mg
A18566-10IDO/TDO-IN-1 10mg
A18566-50IDO/TDO-IN-1 50mg
T84728-01(R) -IDO/TDO-IN-1
A18566-100IDO/TDO-IN-1 100mg

Popular Products