NS-102

• Description :

  NS-102 is a selective kainate (GluK2) receptor antagonist. NS-102 is a potent GluR6/7 receptor antagonist[1][2][3].

• CAS Number :

  [136623-01-3]

• UNSPSC :

  12352005

• Target :

  IGluR

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ns-102.html

• Purity :

  98.51

• Solubility :

  DMSO : 4 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C1NC2=C(C=C([N+]([O-])=O)C3=C2CCCC3)/C1=N/O

• Molecular Formula :

  C12H11N3O4

• Molecular Weight :

  261.23

• References & Citations :

  [1]Selva Baltan Tekkök, et al. Excitotoxic mechanisms of ischemic injury in myelinated white matter. J Cereb Blood Flow Metab. 2007 Sep;27 (9) :1540-52.|[2]P Liang, et al. Sevoflurane activates hippocampal CA3 kainate receptors (Gluk2) to induce hyperactivity during induction and recovery in a mouse model. Br J Anaesth. 2017 Nov 1;119 (5) :1047-1054.|[3]Barbara Gisabella, et al. Kainate receptor-mediated modulation of hippocampal fast spiking interneurons in a rat model of schizophrenia. PLoS One. 2012;7 (3) :e32483.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported