RBM1-151

CAT: 0804-HY-N15826Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-N15826Size:1 Each
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Description
RBM1-151, a 1-deoxy derivative and vinilog of RBM14-C12 (HY-150163), as a fluorogenic substrate of Amidases (HY-P2736) (Ex/Em) . RBM1-151 is hydrolyzed by acid ceramidase (AC) ((appKm = 7.0 μM; appVmax = 99.3 nM/min), N-acylethanolamine-hydrolyzing acid amidase (appKm = 0.73 μM; appVmax = 0.24 nM/min), and fatty Acid amide hydrolase (FAAH) (appKm = 3.6 μM; appVmax = 7.6 nM/min) but not by other ceramidases. RBM1-151 is applicable for basic biological studies of lipid amidase function, as well as potential diagnostic/prognostic evaluations of diseases involving dysregulated AC, NAAA, or FAAH (Farber disease, cancer) [1][2].
CAS Number
[3077081-47-8]
UNSPSC
12352005
Target
Ceramidase; Fluorescent Dye
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CCCCCCCCCCCC(N[C@@H](C)[C@H](O)C/C=C/COC1=CC=C(C=CC(O2)=O)C2=C1)=O
Molecular Formula
C28H41NO5
Molecular Weight
471.63
References & Citations
[1]Casasampere M, et al. A fluorogenic substrate for the detection of lipid amidases in intact cells. J Lipid Res. 2024 Mar;65 (3) :100520. |[2]Ciuffreda P, et al. Fluorescence-Based Enzyme Activity Assay: Ascertaining the Activity and Inhibition of Endocannabinoid Hydrolytic Enzymes. Int J Mol Sci. 2024 Jul 13;25 (14) :7693.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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