PLP (139-151)

CAT: 0804-HY-P0129-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P0129-01Size:1 mg
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Description
PLP (139-151) is amino acid residue 139 to 151 of myelin proteolipid protein (PLP) used to induce experimental autoimmune encephalomyelitis (EAE) .
CAS Number
[131334-43-5]
UNSPSC
12352209
Target
Others
Type
Peptides
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/PLP_139-151.html
Purity
99.74
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
N[C@@H](CC1=CN=CN1)C(N[C@@H](CS)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CC2=CN=CN2)C(N3[C@@H](CCC3)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O)=O)=O
Molecular Formula
C72H104N20O16S
Molecular Weight
1537.79
References & Citations
[1]Kuchroo VK, et al. Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides. Pathobiology. 1991;59 (5) :305-12.|[2]Sobel RA, et al. Acute experimental allergic encephalomyelitis in SJL/J mice induced by a synthetic peptide ofmyelin proteolipid protein. J Neuropathol Exp Neurol. 1990 Sep;49 (5) :468-79.|[3]Bebo BF Jr, et al. Male SJL mice do not relapse after induction of EAE with PLP 139-151. J Neurosci Res. 1996 Sep 15;45 (6) :680-9.|[4]Coda AR, et al. In vivo imaging of CNS microglial activation/macrophage infiltration with combined [18F]DPA-714-PET and SPIO-MRI in a mouse model of relapsing remitting experimental autoimmune encephalomyelitis. Eur J Nucl Med Mol Imaging. 2021 Jan;48 (1) :40-52.|[5]Turvey ME, et al. Quantitative proteome profiling of CNS-infiltrating autoreactive CD4+ cells reveals selective changes during experimental autoimmune encephalomyelitis. J Proteome Res. 2014 Aug 1;13 (8) :3655-70.|[6]Zhang H, et al. Intrinsic and induced regulation of the age-associated onset of spontaneous experimental autoimmune encephalomyelitis. J Immunol. 2008 Oct 1;181 (7) :4638-47.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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Alternative Products

CatalogName
M41509-01[Ala144] - PLP (139 - 151) A144 - PLP (139 - 151)
5-00035[Ala144] - PLP (139 - 151) A144 - PLP(139 - 151)
M41508-01[Gln144] - PLP (139 - 151), Q144 - PLP (139 - 151)
5-00188[Gln144] - PLP (139 - 151), Q144 - PLP(139 - 151)
E-PP-0035-01[Ala144]-PLP (139-151) A144-PLP (139-151)
M41506-01[Leu144] - PLP (139 - 151), L144 - PLP (139 - 151)
E-PP-0188-01[Gln144]-PLP (139-151), Q144-PLP (139-151)
E-PP-0216-01[Leu144]-PLP (139-151), L144-PLP (139-151)
5-00216[Leu144] - PLP (139 - 151), L144 - PLP(139 - 151)
SB128-5MGPLP (139-151)

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