AMG-151

• Description :

  AMG-151 (ARRY-403) is a glucokinase agonist with fasting plasma glucose (FPG) lowering activity. AMG-151 showed a significant linear dose-response trend compared with placebo in a randomized, placebo-controlled Phase IIa study. The use of AMG-151 was associated with a higher incidence of hypoglycemia and hypertriglyceridemia. AMG-151 may serve as a potential compound for the inhibition of type 1 diabetes[1].

• CAS Number :

  [1138669-65-4]

• Product Name Alternative :

  ARRY-403

• UNSPSC :

  12352005

• Target :

  Endogenous Metabolite

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/amg-151.html

• Smiles :

  O[C@H](CO)C1=NSC(NC2=NC=C(C=C2OC3=CC=CN=C3C)SC4=NC=CC=C4)=N1

• Molecular Formula :

  C20H18N6O3S2

• Molecular Weight :

  454.53

• References & Citations :

  [1]AMG 151 (ARRY-403), a novel glucokinase activator, decreases fasting and postprandial glycaemia in patients with type 2 diabetes

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported