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AMG-151

CAT: 0804-HY-125316-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-125316-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AMG-151 (ARRY-403) is a glucokinase agonist with fasting plasma glucose (FPG) lowering activity. AMG-151 showed a significant linear dose-response trend compared with placebo in a randomized, placebo-controlled Phase IIa study. The use of AMG-151 was associated with a higher incidence of hypoglycemia and hypertriglyceridemia. AMG-151 may serve as a potential compound for the inhibition of type 1 diabetes[1].
CAS Number
1138669-65-4
Product Name Alternative
ARRY-403
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/amg-151.html
Smiles
O[C@H](CO)C1=NSC(NC2=NC=C(C=C2OC3=CC=CN=C3C)SC4=NC=CC=C4)=N1
Molecular Formula
C20H18N6O3S2
Molecular Weight
454.53
References & Citations
[1]AMG 151 (ARRY-403), a novel glucokinase activator, decreases fasting and postprandial glycaemia in patients with type 2 diabetes
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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