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JTE-151

CAT: 0804-HY-155487-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-155487-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JTE-151 is a RORĪ³ inhibitor, which can suppress overactive immune response through inhibition of RORĪ³ related to the activation of Th17 cells, making JTE-151 possible to be used in autoimmune disease research[1].
CAS Number
[1404380-58-0]
UNSPSC
12352005
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jte-151.html
Purity
99.34
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
ClC1=CC(C)=CC=C1NC(C[C@H](CCC(O)=O)C2=NOC([C@@H]3C[C@H](CC(C)(C)C)C3)=C2C4CC4)=O
Molecular Formula
C28H37ClN2O4
Molecular Weight
501.06
References & Citations
[1]Hiromu Takiguchi, et al. Practical Synthesis of Chiral 3- (Hydroxyiminomethyl) adipic Acid, a Key Intermediate of the ROR-Ī³ Inhibitor JTE-151, via Crystallization-Induced Dynamic Resolution
Shipping Conditions
Room Temperature
Storage Conditions
-20Ā°C, 3 years; 4Ā°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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