JTE-151

• Description:

  JTE-151 is a RORγ inhibitor, which can suppress overactive immune response through inhibition of RORγ related to the activation of Th17 cells, making JTE-151 possible to be used in autoimmune disease research[1].

• UNSPSC:

  12352005

• Target:

  ROR

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/jte-151.html

• Purity:

  99.34

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  ClC1=CC(C)=CC=C1NC(C[C@H](CCC(O)=O)C2=NOC([C@@H]3C[C@H](CC(C)(C)C)C3)=C2C4CC4)=O

• Molecular Formula:

  C28H37ClN2O4

• Molecular Weight:

  501.06

• References & Citations:

  [1]Hiromu Takiguchi, et al. Practical Synthesis of Chiral 3- (Hydroxyiminomethyl) adipic Acid, a Key Intermediate of the ROR-γ Inhibitor JTE-151, via Crystallization-Induced Dynamic Resolution

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1404380-58-0]