EGFR-IN-151

CAT: 0931-T206456-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T206456-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

EGFR, ERK, STAT, Apoptosis

Related Pathways

JAK/STAT signaling, Apoptosis, Tyrosine Kinase/Adaptors, MAPK, Angiogenesis, Stem Cells

Bioactivity

EGFR-IN-151 (Compound 10) inhibits EGFR and its downstream signaling pathways ERK/STAT3. It effectively suppresses the proliferation of various lung cancer cells, with IC50 values of 11.7, 5.19, 7.32, and 1.53 μM for NCI-H1781, HCC827, NCI-H3255, and NCI-H1975, respectively. Additionally, EGFR-IN-151 hinders colony formation and cell migration in H1975, induces G1 phase cell cycle arrest, and triggers apoptosis in H1975 cells.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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GTR19258769-01	EGFR-IN-151
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A136069	Anti-EGFR/ERBB1/HER1 (MM-151) Biosimilar (Monoclonal, IgG)
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EGFR-IN-151

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