EGFR-IN-151

• Target:

  EGFR|||ERK|||STAT|||Apoptosis

• Related Pathways:

  JAK/STAT signaling|||Apoptosis|||Tyrosine Kinase/Adaptors|||MAPK|||Angiogenesis|||Stem Cells

• Bioactivity:

  EGFR-IN-151 (Compound 10) inhibits EGFR and its downstream signaling pathways ERK/STAT3. It effectively suppresses the proliferation of various lung cancer cells, with IC50 values of 11.7, 5.19, 7.32, and 1.53 ?M for NCI-H1781, HCC827, NCI-H3255, and NCI-H1975, respectively. Additionally, EGFR-IN-151 hinders colony formation and cell migration in H1975, induces G1 phase cell cycle arrest, and triggers apoptosis in H1975 cells.

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C