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Antitumor agent-151

CAT: 0804-HY-162462Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162462Size:1 Each
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Description
Antitumor agent-151 (7k) is a significant HsClpP agonist and an antileukemia drug candidate. Antitumor agent-151 (7k) exhibits remarkably enhanced proteolytic activity of HsClpP (EC50 = 0.79 μM) and antitumor activity in vitro (IC50 = 0.038 μM) . Antitumor agent-151 (7k) induces apoptosis[1].
CAS Number
9007-83-4
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-151.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(CCN(C1)CC2=CC(C#N)=CC=C2)N3)N=C3NCC4=CC=C(C=C4)F
Molecular Formula
C22H20FN5O
Molecular Weight
389.43
References & Citations
[1]Xinrong Xiang, et al. Rational Design of a Novel Class of Human ClpP Agonists through a Ring-Opening Strategy with Enhanced Antileukemia Activity. J Med Chem. 2024 Apr 25;67 (8) :6769-6792.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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