H-151

• Description:

  H-151 is a potent, selective and covalent antagonist of STING that has noteworthy inhibitory activity both in cells and in vivo. H-151 reduces TBK1 phosphorylation and suppresses STING palmitoylation. H-151 can be used for the research of autoinflammatory disease[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  STING

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/h-151.html

• Purity:

  99.86

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (NC1=CNC2=C1C=CC=C2) NC3=CC=C (CC) C=C3

• Molecular Formula:

  C17H17N3O

• Molecular Weight:

  279.34

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559 (7713) :269-273.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  941987-60-6