H-151

CAT: 0804-HY-112693-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-112693-01Size:5 mg
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Description
H-151 is a potent, selective and covalent antagonist of STING that has noteworthy inhibitory activity both in cells and in vivo. H-151 reduces TBK1 phosphorylation and suppresses STING palmitoylation. H-151 can be used for the research of autoinflammatory disease[1].
CAS Number
[941987-60-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
STING
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/h-151.html
Purity
99.86
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CNC2=C1C=CC=C2)NC3=CC=C(CC)C=C3
Molecular Formula
C17H17N3O
Molecular Weight
279.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559 (7713) :269-273.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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