AP-7-168

• Description :

  AP-7-168, molecular glues, is a β-arrestin-biased negative allosteric modulator of the β2-adrenergic receptor (β2AR) . AP-7-168 can promote β2AR homodimerization and inhibit GRK5-mediated β2AR phosphorylation. AP-7-168 can sustain bronchorelaxation in cell and tissue. AP-7-168 can be used for the researches of inflammation and immunology, such as asthma[1].

• UNSPSC :

  12352005

• Target :

  Adrenergic Receptor; Molecular Glues

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling; PROTAC

• Field of Research :

  Inflammation/Immunology

• Smiles :

  FC1=C(C=C(C=C1)NC2=NC3=CC=C(C=C3C(NC4CCCCC4)=N2)Br)F

• Molecular Formula :

  C20H19BrF2N4

• Molecular Weight :

  433.29

• References & Citations :

  [1]Jiemin Shen, et al. A biased allosteric modulator functions as a molecular glue to induce β2AR dimerization. bioRxiv. October 22, 2025.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  β adrenergic receptor

• CAS Number :

  [2816062-15-2]