AP-7-168

CAT: 0804-HY-179226Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-179226Size:1 Each

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Description

AP-7-168, molecular glues, is a β-arrestin-biased negative allosteric modulator of the β2-adrenergic receptor (β2AR) . AP-7-168 can promote β2AR homodimerization and inhibit GRK5-mediated β2AR phosphorylation. AP-7-168 can sustain bronchorelaxation in cell and tissue. AP-7-168 can be used for the researches of inflammation and immunology, such as asthma[1].

CAS Number

2816062-15-2

UNSPSC

12352005

Target

Adrenergic Receptor; Molecular Glues

Related Pathways

GPCR/G Protein; Neuronal Signaling; PROTAC

Field of Research

Inflammation/Immunology

Smiles

FC1=C(C=C(C=C1)NC2=NC3=CC=C(C=C3C(NC4CCCCC4)=N2)Br)F

Molecular Formula

C20H19BrF2N4

Molecular Weight

433.29

References & Citations

[1]Jiemin Shen, et al. A biased allosteric modulator functions as a molecular glue to induce β2AR dimerization. bioRxiv. October 22, 2025.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

β adrenergic receptor

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