ST-168

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  ST-168 is a potent inhibitor of PI3K and MEK. ST-168 displays improved PI3K and MEK1 isoform inhibition. ST-168 demonstrated a 2.8-, 2.7-, 23-, and 2.5-fold improved inhibition toward the PI3K?, PI3K?, PI3K?, and PI3K? isoforms and a 2.2-fold improvement in MEK1 inhibition respectively, as compared to a previous lead ST-162 in in vitro enzymatic inhibition assays. ST-168 demonstrated superior tumoricidal efficacy over ST-162 in an A375 melanoma spheroid tumor model.

• Smiles:

  O=C(NOCCOCCOCCOCCC(N1CCN(C2=NC(N3C(C(F)F)=NC4=CC=CC=C34)=NC(N5CCOCC5)=N2)CC1)=O)C6=CC=C(F)C(F)=C6NC7=CC=C(I)C=C7F

• Molecular Formula:

  C41H44F5IN10O7

• Molecular Weight:

  1010.76

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C