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Lipid-168

CAT: 0013-GTR19259979-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19259979-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LIPID168 (pKa ~6.5) ​​ is an optimized ionizable lipid engineered for in vivo mRNA delivery to hematopoietic stem cells (HSCs) in bone marrow. Developed by ​​Yoltech Therapeutics​​ through high-throughput screening of lipid libraries, it features a ​​diethylamino head group​​ and a tailored hydrophobic tail structure that enables antibody-free targeting. When Lipid 168 was formulated into lipid nanoparticles (LNPs), it achieved ​​48.5% base editing efficiency​​ in bone marrow cells —surpassing benchmarks like LIPID-028 (19.7%) —and reduced off-target liver editing from 71% to 19% by incorporating ​​miR-122 target sequences​​. In humanized β-thalassemia models, LNP 168 delivered ABE8e mRNA/sgRNA to patient-derived HSCs, yielding ​​42.6% editing at the HBG promoter​​, reactivating fetal hemoglobin (γ-globin) and rescuing erythroid defects . Its bone marrow specificity is driven by a unique ​​protein corona​​ enriched in albumin, fibronectin, and fibrinogen . Safety studies confirmed transient immune responses and no cumulative toxicity . LIPID-168 represents a promising non-viral platform for curative gene therapies in blood disorders.
Field of Research
Metabolism Research
Purity
>95%
Smiles
CCCCCCCCCNC (=O) C (CCCCCCCCC (=O) OCC (CCCC) CCCCCC) N (CCCN (CC) CC) C (=O) CCCCCCCC (=O) OCC (CCCC) CCCCCC
Molecular Formula
C60H117O6N3
Molecular Weight
975.89
Notes
For research use only.

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