Apoptosis inducer 52

CAT: 0804-HY-179124Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-179124Size:1 Each
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Description
Apoptosis inducer 52 is a derivative of flutamide that induces apoptosis in prostate cancer cells. Apoptosis inducer 52 promotes apoptosis by activating both intrinsic and extrinsic apoptotic pathways, without generating reactive oxygen species (ROS) . Apoptosis inducer 52 triggers caspase 3/7 activity and the externalization of phosphatidylserine, leading to cell cycle arrest at the G0/G1 phase. Apoptosis inducer 52 can be used for the research of androgen receptor (AR) -dependent and -independent prostate cancers and leukemia[1].
UNSPSC
12352005
Target
Apoptosis; Caspase
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C1=CC=CN=C1NC2=CC=CC(C(F)(F)F)=C2)[Se]CC(NC3=CC=CC(C(F)(F)F)=C3)=O
Molecular Formula
C22H15F6N3O2Se
Molecular Weight
546.32
References & Citations
[1]Morán-Serradilla C, et al. Innovative Se-Flutamide Derivatives: Enhanced Activity Toward Androgen Receptor (AR) -Dependent and -Independent Prostate Cancer Cells. Arch Pharm (Weinheim) . 2025;358 (10) :e70119.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 7; Caspase 8; Caspase 9

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