Apoptosis inducer 52

• Description :

  Apoptosis inducer 52 is a derivative of flutamide that induces apoptosis in prostate cancer cells. Apoptosis inducer 52 promotes apoptosis by activating both intrinsic and extrinsic apoptotic pathways, without generating reactive oxygen species (ROS) . Apoptosis inducer 52 triggers caspase 3/7 activity and the externalization of phosphatidylserine, leading to cell cycle arrest at the G0/G1 phase. Apoptosis inducer 52 can be used for the research of androgen receptor (AR) -dependent and -independent prostate cancers and leukemia[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Caspase

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  O=C(C1=CC=CN=C1NC2=CC=CC(C(F)(F)F)=C2)[Se]CC(NC3=CC=CC(C(F)(F)F)=C3)=O

• Molecular Formula :

  C22H15F6N3O2Se

• Molecular Weight :

  546.32

• References & Citations :

  [1]Morán-Serradilla C, et al. Innovative Se-Flutamide Derivatives: Enhanced Activity Toward Androgen Receptor (AR) -Dependent and -Independent Prostate Cancer Cells. Arch Pharm (Weinheim) . 2025;358 (10) :e70119.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Caspase 3; Caspase 7; Caspase 8; Caspase 9